Jun 18, 2020
Photodynamic therapy (PDT) has become a preferred treatment of
field cancerization. Dr. Vincent DeLeo talks to Dr. Martin Miller
about results from a split-sided study evaluating the efficacy of
CO2 laser ablative fractional resurfacing pretreatment followed by
conventional PDT for treatment of actinic keratoses (AKs). They
discuss the clinical benefits of PDT for treatment of AKs as well
as future directions for this combination therapy for nonmelanoma
We also bring you the latest
in dermatology news and research:
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Key takeaways from this episode:
- Photodynamic therapy (PDT) provides consistent predictable
results and healing periods without variations in response seen
with topical therapies.
- In a split-sided study, pretreatment with CO2 laser ablative
fractional resurfacing in combination with conventional PDT showed
increased efficacy of AK clearance vs. conventional PDT alone.
- This combination therapy showed clearance of superficial basal
cell carcinoma, but nodular basal cell carcinoma and squamous cell
carcinoma in situ persisted at 6 months.
- Side effects of treatment included hypopigmentation in face and
scalp areas on the laser-treated side.
- Future directions for treatment may include aminolevulinic acid
gel 10% with standard PDT as well as combination with a red-light
source to achieve deeper penetration into the skin.
Hosts: Nick Andrews, Vincent
A. DeLeo, MD (Keck School of Medicine of the University of
Southern California, Los Angeles)
B. Miller, MD (University of California, San Francisco)
Disclosures: Dr. DeLeo is a consultant for
Estée Lauder. Dr. Miller received grant support and study drug from
DUSA Pharmaceuticals Inc.
Show notes by:
Alicia Sonners, Melissa Sears
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